Endocrine Abstracts

Background: Haploinsufficiency of the GATA3 gene located on chromosome 10p15, is well-recognised as the cause of hypoparathyroidism, sensorineural deafness and renal dysgenesis; the HDR syndrome. A number of abnormalities within the GATA3 gene have been identified, with varying phenotypic characteristics. GATA3 is associated with other abnormalities including, abnormalities of Mullerian structures, hypomagnesia, hemimegalenencephaly and diabetes mell...

Objective: The aim of the study was to determine frequency of insulin resistance, in individuals with type 1 diabetes mellitus and the link between insulin resistance and cardiovascular disease, sex hormones. The task of the research is to determine the frequency of insulin resistance among people with diabetes mellitus type 1. To determine association between eGDR and age, sex, cardiovascular disease, chronic complications of diabetes and sex hormones. To determine associatio...

Introduction: Multiple endocrine neoplasia type 2A (MEN2A) is a rare autosomal-dominant hereditary cancer syndrome characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, and primary hyperparathyroidism. Pregnancy complicating MEN2A is exceedingly rare, with only 29 reported cases. This case discusses an unusual instance where an enlarged thyroid, displaying sonographic features indicative of cancer, led to the diagnosis and management of RET proto-oncogene-posit...

Introduction: Amiodarone is an effective drug in the management of supraventricular arrhythmias. Due to its composition rich in iodine and pharmacological properties can cause thyroid dysfunction in 15–20% of the treated patients. Clinically it can present in the form of amiodarone-induced hypothyroidism or amiodarone-induced thyrotoxicosis. This latter situation may result from an excess of iodine supply, glandular destruction or both pathogenic mechanisms.<p class="...

Introduction: Recent studies seem to support a bidirectional positive interaction between aldosterone and parathyroid hormone (PTH). Understanding the normal physiological relationship between renin-angiotensin-aldosterone system (RAAS) and PTH is of clinical interest because their inappropriate activity may negatively impact cardiovascular and skeletal health.Objective: To evaluate the presence of an interaction between aldosterone and PTH in a cohort o...

Introduction: Autoimmune Addison disease requires lifelong glucocorticoid and mineralocorticoid replacement. Optimal therapy is not standardized and must balance adequate hormone substitution with prevention of treatment-related complications.Objective: Assessment of patients followed at our department: epidemiology, associated conditions, treatment, cumulative hydrocortisone dose and comorbidities.Methods: Review of clinical recor...

Introduction: Obesity is a chronic disease associated with multiple comorbidities, defined by BMI, without considering the metabolic state of the patient. There are few data on the proportion of obese patients without metabolic syndrome (MS).Objective: To characterize patients considered to be metabolically healthy (MH) followed at the obesity outpatient clinic of one University Hospital, and to compare this group with a group of obese patients with MS.<...

Introduction: Cushing’s disease (CD) is a rare disorder caused by an ACTH-secreting pituitary adenoma. Transsphenoidal surgery (TSS) is the recommended first-line treatment. However, an equivocal or even normal preoperative MRI can preclude the surgical management and the outcome of these patients.Objectives: Evaluate the relationship between preoperative MRI and TSS efficacy in patients with CD.Methods: Retrospective cohort s...

Introduction: Continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI) are forms of intensified insulin therapy and the most used regimens for type 1 diabetes (T1D). Owing to its continuous basal output, hypoglycaemic events tend to be rarer with CSII. Our goal was to evaluate the differences in nocturnal hypoglycemia between these two treatment strategies.Methods: Retrospective analysis of 61 patients who had performed continu...

Background: Peripheral neuropathy is the most prevalent chronic complication in diabetes and increases the risk of sarcopenia in these patients. Hand grip strength (HGS) measurement is a good predictor for the presence of sarcopenia.The aim of the study was toevaluate HGS in diabetes patients with and without neuropathy and the clinical and paraclinical parameters that are correlated with HGS.Methods: We evaluated 102 diabetes pati...